I am surprised Nintendo (and other copyright holders) aren't going after the multi-game cabinets and the like. I know of a number of places running multi-game cabinets (that most likely contain games made by Nintendo in them) as well as companies selling multi-game cabinets on their site (again likely with games made by Nintendo in them)
And I am very surprised we dont see more action taken on people selling bootleg "repo" carts (or other bootlegs) on sites like eBay, especially given that eBay has tools to make going after such things easy (easy ways to get stuff taken down etc)
They also need to get more of their titles onto the virtual console and stop messing around and get the thing onto the Switch (under the same easy "anyone with the system can log on and just pay a one-off price per game" model that has worked so well on their other consoles and none of this extra pay-for-online-access or other crap that has been rumored). Oh and make more of those mini consoles, those seem to be selling like crazy and I am sure the rumored N64 mini (or a Game Boy mini that you could take on the go with you) would sell just as well.
IMO the Virtual Console and retro minis (NES and SNES) have done more to reduce piracy than any amount of enforcement action against pirate sites.