best low impact way to lose weight (if you really want to WORK at it) is an elliptical machine. You can burn mad calories with it without messing up your joints.
As far as running goes, 6 weeks before I got my anchors pinned on we quickly worked up to 7+ miles, 3 times a week. I lost about 20lbs then... put it back on within a year though.
Just broke my personal record for number of consecutive days without dying!
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