Had one at my last job cant think of the name unfortunatly (sorry). It was decent. They installed it on all the pcs automatically. Never even noticed it running. I usually scheduled it to do the incremental backup in the middle of the night or during lunch.
A few dudes I work with use that particular one right now and they are not very happy with it. It is slow and basically took over their computers. Though I have heard of a couple of other dudes saying it works fine.
The trick is finding one that is not aggressive and goes slow in the backups... The nice bit about getting it onto a central serve is you can just dump it all into a tape backup and do a standard tape rotation on it.