http://www.retrode.com/

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The Ultimate Retro Gaming Adapter
The Retrode is the world’s most versatile (and fun!) USB adapter for vintage video games. Revive the good old 16-bit times on your computer/smartphone/tablet, using your original cartridges and controllers!

Features
Cartridge slots for *Sega Genesis/Mega Drive and *Nintendo SNES/SFC games. Access ROM (program/data) and SRAM (savegames)!
2×2 ports for *Sega and *SNES controllers. Combine them for multi-player fun with up to 4 people!
Driverless operation on any USB host, under any OS, using any emulator.
Easy to use, configure and update.
Expandable using plug-in adapters.
Dimensions and weight: 162mm x 80mm x 42mm, 220g (6.4″ x 3.2″ x 1.7″, 0.5lbs)
Made in Germany.
Includes USB cable and instruction sheet. Suggested retail price: EUR 65 / USD 85.
Available Jan 23, 2012. Order now on this website and through various distribution partners (Europe, USA).
* These trademarks of other manufacturers are used solely to identify certain products. We are in no way associated or affiliated with their owners.

How it works
Find and install emulator. (If you are new to emulation, you may want to check out one of the numerous emulation-related portals.)
Plug cartridge into Retrode, and connect controllers. Of course, if you only want to use either the cartridge or a controller, that’s fine with us.
Connect Retrode to computer. No drivers needed.
Play! Load ROM into the emulator, configure the controllers, and you’ll be playing in no time.