House of the Dead 4 ran on Sega's Lindbergh hardware, the particular model of which had a 3.0GHz Pentium 4 and a GeForce 6-series GPU.
MAME is an emulator, not an OS shim like the utility you tried to use. As such, the goal would be to emulate a PC of this particular configuration - which, even with a lightning-fast recompiler and GPU acceleration, is unlikely to approach anything resembling playable speeds.
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