You will need ROM files for each system. These are just like arcade ROMs, have a name, and are loaded just like an arcade game. Individual software titles (e.g. Super Mario World) have their own set of ROMs that are associated with a type of media, e.g. cartridge. You associate the media with the system either after you load it or when MAME starts by passing a command argument.
You can run the SNES driver from MAME and it will prompt you to load a cartridge. You can also load software at anytime by using the in-game menu. Many systems have an OS that loads in which case it won’t prompt for a file to be loaded.
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