My frontend Emu Loader have partial support for 3840x2160 resolution. I myself have a 4K res monitor and I'm slowly adapting the frontend for this resolution. You can change font sizes and increase panel sizes on some screens.
I use 100% scale DPI in Windows desktop settings... if you use higher DPI scale, then it will not make any difference because Emu Loader doesn't support DPI scale... afaik, no frontend does that.