You have to enable mouse support in the mame.ini file. In mame.ini, change the following:
Mouse 0 to Mouse 1
Then start the game, Press the TAB key, go to Input (This Machine), and change whatever you want to change. For instance, if you want the LEFT arrow to be controlled by your mouse, then press ENTER on the P1 LEFT and move your mouse to the left to reprogram it.
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