HHHHhhmmm...I reinstalled MAME into a new folder and created a new mame.ini with the -cc command. It works just fine that way. Now I gotta figure out what setting I had originally that the new version doesn't like :-/
Windows 11 64 bit OS
Intel Core i7-10700
Nvidia GeForce RTX 2060 6GB
32GB DDR4 RAM