My understanding, and I could well be wrong, is that you shouldn't use v-sync with mame. Not all games run at the same speed/refresh rate and, unless it was changes recently, that will cause games to run faster or slower than intended when v-sync is enabled; As you have found by enabling vsync on a 120hz monitor.
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Re: Disaster with MAME after migrating from XP 32 to Win7 64
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