I was using Mame plus last year but now I think the best option is using the original Mame64.exe + Emuloader.
Emuloader is super simple, fast, great looking, etc..
It takes 5 secs to start, click on the game you want to play and voila, plus you can add Model 2 and Model 3 games.
Hyperspin look nice but that's just overkill for me..... all those .avi and animation, people spend most of their time looking at their menus rather than play games.